![]() ![]() Graft copolymers (SA-g-AMPS and SA-g-SVBS) were characterized by 1H NMR, FTIR, XRD and DSC. In the first step, 2-acrylamido-2-methyl-1-propanesulphonic acid (AMPS) and sodium 4-vinylbenzene sulfonate (SVBS) are grafted on to SA by utilizing the simple free radical polymerization technique. In this work, we have fabricated environmentally safe and economic PEMs based on sulfonate grafted sodium alginate (SA) and poly(vinyl alcohol) (PVA). If environmentally benign materials are created with biodegradable ones, PEMs can evolve into practical technology. Polyelectrolyte membranes (PEMs) are a novel type of material that is in high demand in health, energy and environmental sectors. Finally, the results demonstrate that TMGA and TMGA-Ag are promising candidates for anti-cancer drug delivery and the inactivation of pathogenic bacteria, respectively. The antimicrobial activity of TMGA-Ag hydrogels was studied against Staphylococcus aureus and Klebsiella pneumonia. The effects of treatment on HCT116 human colon cancer cells were assessed via cell viability and cell cycle analysis. These release data were best fitted with the Korsemeyer–Peppas transport mechanism, with n = 0.91. The drug release behavior was examined with kinetic models such as zero-order, first-order, Higuchi, Hixson Crowell and Korsmeyer–Peppas. ![]() Doxorubicin hydrochloride, a chemotherapeutic agent successfully encapsulated with maximum encapsulation efficiency, i.e., 69.20 ± 1.2, was used in in vitro release studies in pH physiological and gastric environments at 37 ☌. TMGA and TMGA-Ag hydrogels were investigated to study the characteristics of drug delivery and antimicrobial study. The synthesized hydrogels and silver nanocomposites were characterized via UV, FTIR, XRD, SEM and TEM. Swelling kinetics and the equilibrium swelling behavior of the TMGA hydrogels were investigated in various pH environments, and the maximum % of equilibrium swelling behavior observed was 2882 ± 1.2. In addition, these hydrogels were used as templates for the green synthesis of silver nanoparticles (13.4 ± 3.6 nm in diameter, TMGA-Ag) by using leaf extract of Teminalia bellirica as a reducing agent. In this paper, novel pH-responsive, semi-interpenetrating polymer hydrogels based on tamarind gum-co-poly(acrylamidoglycolic acid) (TMGA) polymers were synthesized using simple free radical polymerization in the presence of bis phosphate as a crosslinker and potassium persulfate as a initiator.
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